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They operate through complementary mechanisms and don't have known negative interactions

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A small number of users report feeling overly relaxed or sedated if taking DSIP too early in the evening, leading to difficulty staying awake until intended bedtime

Jelovac, N et al

Research published in Molecules showed that the AEDG peptide sequence stimulates gene expression and protein synthesis in neuronally differentiated cells, increasing synthesis of markers associated with neurogenic differentiation